Perugia, Italy: Patients with a history of migraine headaches may be suffering from a clinical deficiency of the endocannabinoid system, according to clinical trial data published in the European Journal of Clinical Pharmacology.
Investigators at Italy’s University of Perugia, Department of Public Health, reported that patients with chronic migraines possessed "significantly lower" levels of the endogenous cannabinoids anandamide and 2-arachidonylglycerol (2-AG) in their platelets compared to age-matched controls.
"These data support the potential involvement of a dysfunctioning of the endocannabinoid and serotonergic systems in the pathology of chronic migraine and medication-overuse headaches," researchers’ concluded.
A previous paper published in the journal Neuroendocrinology Letters similarly suggested that migraine, fibromyalgia, and other treatment-resistant conditions may be associated with dysfunctions in the endocannabinoid system. This system is believed to play a primary role in regulating humans' mood, appetite, skeletal development, motor coordination, digestion, and reproduction.
Full text of the study, "Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: relation with serotonin levels," appears in the November issue of the European Journal of Clinical Pharmacology.
Benefits of Cannabis in Migraine, and other Treatment-Resistant Conditions - Russo EB
1 comment:
Oh yes, I think so too. I used to have a terrible time with head pain and vomiting. Often I hid out in a totally dark room and away from even the least of noises. I remember crying in pain only to make it all worse. I took OTC meds to try to relieve the pain but over time none of them worked. I tried a few different perscriptions for migraines but the all made me sick and aquired some severe digestive problems. So I decided to investigate alternative medicine and found that some strains of cannabis worked good for pain, some relax and deminish my nausia. I am a firm believer in the medicinal powers of cannabinoids.
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